Rapid microwave-enhanced, solventless Sonogashira coupling reaction on alumina

GW Kabalka, L Wang, V Namboodiri, RM Pagni

Index: Kabalka, George W.; Wang, Lei; Namboodiri, Vasudevan; Pagni, Richard M. Tetrahedron Letters, 2000 , vol. 41, # 27 p. 5151 - 5154

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Citation Number: 152

Abstract

The Sonogashira coupling reaction of terminal alkynes and aryl or alkenyl halides provides an efficient route to aryl alkynes. 1., 2., 3. and 4. Numerous applications to natural product syntheses have been reported, including the construction of complex enediyne antibiotics. 5., 6. and 7. The reaction is generally carried out in organic solvents such as amines, benzene, THF and DMF along with complex palladium catalysts which are soluble in these solvents. These ...