NOSH-Aspirin: A novel nitric oxide–hydrogen sulfide-releasing hybrid: A new class of anti-inflammatory pharmaceuticals

R Kodela, M Chattopadhyay…

Index: Kodela, Ravinder; Chattopadhyay, Mitali; Kashfi, Khosrow ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 3 p. 257 - 262

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Citation Number: 74

Abstract

A series of new hybrids of aspirin (ASA), bearing both nitric oxide (NO) and hydrogen sulfide (H2S)-releasing moieties were synthesized and designated as NOSH compounds (1–4). NOSH-1 (4-(3-thioxo-3H-1, 2-dithiol-5-yl) phenyl 2-((4-(nitrooxy) butanoyl) oxy) benzoate); NOSH-2 (4-(nitrooxy) butyl (2-((4-(3-thioxo-3H-1, 2-dithiol-5-yl) phenoxy) carbonyl) phenyl)); NOSH-3 (4-carbamothioylphenyl 2-((4-(nitrooxy) butanoyl) oxy) benzoate); and NOSH-4 ( ...