Journal of the American Chemical Society

Esters of Pyridinecarboxylic Acids as Local Anesthetics

FF Blicke, EL Jenner

Index: Blicke; Jenner Journal of the American Chemical Society, 1942 , vol. 64, p. 1721

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Citation Number: 7

Abstract

It has been reported by Ingersoll and Robbins6 that p-diethylaminoethyl and y- diethylaminopropyl nicotinate are inactive as local anesthetics. They stated that these esters were prepared by them by interaction of the required basic alcohol with nicotinyl chloride; the “nicotinyl chloride” which was employed melted at 264-265'and was preserved over calcium chloride and paraffin. It has been shown by Meyer and Graf6 that the true nicotinyl ...