Journal of medicinal chemistry

Reactivity of Some 2-p-Nitrophenoxy-1, 3, 2-dioxaphospholane 2-Oxides and-dioxaphosphorinane 2-Oxides1

TR Fukuto, RL Metcalf

Index: Fukuto,T.R.; Metcalf,R.L. Journal of Medicinal Chemistry, 1965 , vol. 8, p. 759 - 762

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Citation Number: 32

Abstract

A number of 2-p-nitrophenoxy-1, 3, 2-dioxaphospholane 2-oxides and-dioxaphosphorinane 2-oxides have been prepared and examined for alkaline hydrolysis and anticholinesterase activity. Although the six-membered ring dioxaphosphorinane 2-oxides and the acyclic analog diethyl p-nitrophenpl phosphate (paraoxon) gave comparable rates of liberation of p- nitrophenol in aqiieons NaOH, the cyclic esters were almost void of anticholinesterase ...