Nucleophilic substitution reaction of 1-methoxy-6-nitro-indole

K Yamada, T Kawasaki, T Fujita…

Index: Yamada, Koji; Kawasaki, Toshiya; Fujita, Tomomi; Somei, Masanori Heterocycles, 2001 , vol. 55, # 6 p. 1151 - 1159

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Citation Number: 13

Abstract

抄録: Nucleophilic substitution reaction of 1-methoxy-6-nitroindole (1) was examined. In the reaction with sodium methoxide or sodium cyanide as a nucleophile, 2-and 3-methoxy-6- nitroindoles, and 7-cyano-6-nitroindole were obtained, respectively. A novel methylene homologation at the 3-position was found in the reaction of 1 with sodium methyl sulfide or potassium salt of diethyl malonate to give 3-methylthiomethytyl-6-nitroindole and its 2- ...