Study of the Reaction of Bulky Aryllithium Reagents with 3, 4-Dimethyl-2, 5-diphenyl-1, 3, 2-oxazaphospholidine-2-borane Derived from Ephedrine

M Stephan, D Šterk, B Modec…

Index: Stephan, Michel; Sterk, Damjan; Modec, Barbara; Mohar, Barbara Journal of Organic Chemistry, 2007 , vol. 72, # 21 p. 8010 - 8018

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Citation Number: 13

Abstract

The ring opening of enantiomerically pure 3, 4-dimethyl-2, 5-diphenyl-1, 3, 2- oxazaphospholidine-2-borane (1) with a variety of bulky aryllithium reagents was studied. Our results are not in total agreement with those obtained by others. In fact, several 2, 6- disubstituted aryl groups were successfully appended to the phosphorus atom, furnishing the corresponding (N-ephedrino) phosphine boranes 2a-g with dr> 99: 1. However, when ...