Tetrahedron letters

A new method for the preparation of 2-chlorotrityl resin and its application to solid-phase peptide synthesis

TK Lee, SJ Ryoo, YS Lee

Index: Lee, Tae-Kyung; Ryoo, Sun-Jong; Lee, Yoon-Sik Tetrahedron Letters, 2007 , vol. 48, # 3 p. 389 - 391

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Citation Number: 8

Abstract

2-Chlorotritylchloride (2-CTC) resin was prepared efficiently from 1% DVB-crosslinked polystyrene resin and 1-chloro-2-(dichloro (phenyl) methyl) benzene, which was easily obtained from 2-chlorobenzophenone. This 2-CTC resin showed excellent properties as a support for solid-phase peptide synthesis. Four peptide fragments were obtained in high purity using the resin.