Synthesis and docking studies of novel antitumor benzimidazoles

…, J Li, H Tokuda, RA Ramadan, HI El Diwani

Index: Omar, Mohamed A.; Shaker, Yasser M.; Galal, Shadia A.; Ali, Mamdouh M.; Kerwin, Sean M.; Li, Jing; Tokuda, Harukuni; Ramadan, Raghda A.; El Diwani, Hoda I. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 24 p. 6989 - 7001

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Citation Number: 18

Abstract

In this work, the benzimidazole-pyrrole conjugates 6a–h and benzimidazole-tetracycles conjugates 12–14 were prepared. The cytotoxicity of the compounds 3, 4a–h, 6a–h, 8, 10 and 12–14 was tested against lung cancer cell line A549. Compound 6b exhibited higher activity than the bis-benzoxazole natural product (UK-1), the standard. The tested 4g, h, 6a– h, 10 and 12–14 exhibited remarkable cytotoxicity activity against breast cancer cell line ...