Bioorganic & medicinal chemistry letters

Generation of reactive oxygen species by a persulfide (BnSSH)

T Chatterji, K Keerthi, KS Gates

Index: Chatterji, Tonika; Keerthi, Kripa; Gates, Kent S. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3921 - 3924

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Citation Number: 53

Abstract

Hydropersulfides (RSxSH) have been implicated as important intermediates in the cell- killing action of the anticancer natural products leinamycin and varacin. It has been suggested that persulfides can mediate the conversion of molecular oxygen to reactive oxygen species (O2-, H2O2, and HO). Here, experiments with synthetic benzyl hydrodisulfide (BnSSH) provide direct evidence that persulfides readily decompose to ...