Conformational Study of an Artificial Metal??Dependent Regulation Site for Use in Designer Proteins

E Oheix, N Spencer, LA Gethings…

Index: Oheix, Emmanuel; Spencer, Neil; Gethings, Lee A.; Peacock, Anna F. A. Zeitschrift fur Anorganische und Allgemeine Chemie, 2013 , vol. 639, # 8-9 p. 1370 - 1383

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Citation Number: 2

Abstract

Abstract This report describes the dimerisation of glutathione, and by extension, other cysteine-containing peptides or protein fragments, with a 5, 5'-disubstituted-2, 2'-bipyridine or 6, 6''-disubstituted-2, 2': 6', 2''-terpyridine unit. The resulting bipy-GS 2 and terpy-GS 2 were investigated as potential metal ion dependent switches in aqueous solution, and were found to predominantly adopt the transoïd conformation at physiological pH. Metal ...