Synthesis and antimicrobial activity of substituted 2, 3-dihydro-4H-pyrans

…, AG Leont'eva, TY Pushechkina, MG Voronkov

Index: Stepanova, L. G.; Keiko, N. A.; Malkova, T. N.; Leont'eva, A. G.; Pushechkina, T. Ya.; Voronkov, M. G. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 6 p. 477 - 480 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 6 p. 710 - 713

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Citation Number: 4

Abstract

We have synthesized a number of 2-formyl-2, 5-dialkylthio-2, 3-dihydro-4H-pyrans (la-f) and examined their antimicrobial activity. Compounds (Ib) and (Id) are dimers of 2- alkylthioacroleins, which we have previously obtained by the tlannich condensation of the appropriate alkylthioacetaldehydes with formaldehyde in the presence of diethylamine hydrochioride at room temperature [2].