1, 5-Diazabicyclo [3.1. 0] hexanes and 1, 6-diazabicyclo [4.1. 0] heptanes: a new method for the synthesis, quantum-chemical calculations, and X-ray diffraction study

VV Kuznetsov, SA Kutepov, NN Makhova…

Index: Kuznetsov; Kutepov; Makhova; Lyssenko; Dmitriev Russian Chemical Bulletin, 2003 , vol. 52, # 3 p. 665 - 673

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Citation Number: 4

Abstract

Abstract A new method was developed for the synthesis of 6-substituted 1, 5-diazabicyclo [3.1. 0] hexanes and 7-substituted 1, 6-diazabicyclo [4.1. 0] heptanes by condensation of N- monohalotrimethylene-and N-monohalotetramethylenediamines with carbonyl compounds in the presence of bases. X-ray diffraction studies and quantum-chemical B3LYP/6-31G* calculations demonstrated that the conformations of the resulting bicyclic systems are ...