One??Pot Synthesis of α??Amino Acids from Imines through CO2 Incorporation: An Alternative Method for Strecker Synthesis

T Mita, J Chen, M Sugawara…

Index: Mita, Tsuyoshi; Chen, Jianyang; Sugawara, Masumi; Sato, Yoshihiro Angewandte Chemie - International Edition, 2011 , vol. 50, # 6 p. 1393 - 1396

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Citation Number: 48

Abstract

Carbon dioxide is an abundant and inexpensive carbon source (C1 unit); however, its inertness and gaseous character sometimes hamper its use for efficient CÀC bond-forming reactions in organic synthesis. To overcome this problem, strongly nucleophilic organometallic regents, such as RLi and RMgX, are often used for CÀC bond construction that incorporates CO2.[1] Recently, transition-metal-promoted CO2 fixation reactions, ...