Tetrahedron Letters

A modular approach to α, β-unsaturated N-aryl ketonitrones

TS Hood, CB Huehls, J Yang

Index: Hood, Tyler S.; Bryan Huehls; Yang, Jiong Tetrahedron Letters, 2012 , vol. 53, # 35 p. 4679 - 4682

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Citation Number: 10

Abstract

A modular approach to α, β-unsaturated N-aryl ketonitrones has been developed. Specifically, condensation of anilines and enals followed by alkylation of the resulting α, β- unsaturated imines provided N-allyl anilines, which were subjected to oxidation with Oxone® to form α, β-unsaturated N-aryl ketonitrones. This modular approach is general and provides rapid access to diversely substituted α, β-unsaturated N-aryl ketonitrones with a ...