Researches on Pyrimidines. Certain Derivatives of 2-Propylpyrimidine1

HR Henze, SO Winthrop

Index: Henze; Winthrop Journal of the American Chemical Society, 1957 , vol. 79, p. 2230

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Citation Number: 7

Abstract

In continuation of our investigation of the synthesis of pyrimidine derivatives through condensation of amidines with malonic e~ ters,~*~ we have now studied the interaction of butamidine with ethyl malonate and five ethyl alkylmalonates. The 2-propyl-4, 6 (1, 5)- tetrahydropyrimidinediones thus obtained were converted into 4, 6-dichloro derivatives by treatment with phosphorus oxychloride. With the appropriate reagents and reaction ...