Tetrahedron

Solid-phase preparation of 5′, 3′-heterobifunctional oligodeoxyribonucleotides using modified solid supports

U Asseline, E Bonfils, R Kurfürst, M Chassignol, V Roig…

Index: Asseline; Bonfils; Kurfurst; Chassignol; Roig; Thuong Tetrahedron, 1992 , vol. 48, # 7 p. 1233 - 1254

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Citation Number: 69

Abstract

The solid-phase preparation of oligodeoxyribonucleotides attached to intercalator or reactive groups through their 5′-and (or) 3′-ends is reported. These syntheses implicate the introduction of suitable masked functional groups at the 5′-end of the oligonucleotide by the intermediate of their phosphoramidite derivatives or at the 3′-end of the oligonucleotide using modified solid supports. After full deblocking, the functional groups ( ...