Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application

HW Hamilton, DF Ortwine, DF Worth…

Index: Hamilton, Harriet W.; Ortwine, Daniel F.; Worth, Donald F.; Badger, Edward W.; Bristol, James A.; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 8 p. 1071 - 1079

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Citation Number: 52

Abstract

A set of 56€ &phenylxanthjnea, previously tested for adenosine antagonism (adenosine A1 receptor affinity), was analyzed by quantitative structureactivity relationship (QSAR) techniques. The resulting QSAR revealed that (1) the most potent receptor binders had ...