Synthesis and antiviral evaluation of nucleosides of 5-methylimidazole-4-carboxamide

R Alonso, JI Andres, MT Garcia-Lopez…

Index: Alonso; Andres; Garcia-Lopez; de las Heras; Herranz; Alarcon; Carrasco Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 834 - 838

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Citation Number: 9

Abstract

12-11-ammonolysis of ethyl 1-(2, 3, 5-tri-O-acetyl-P-~-ribo-furanosyl)-5-methylimidazole-4- carboxylate (10) or by deacetylation of 1-(2, 3, 5-tri-0-acety1-PD-ribofuranosyl)-5- methylimidazole-4-carboxamide (1 1)(Scheme I). The synthesis of both per-0-acetylated nucleosides in 66% or 48% yield had been previously reported by ribosylation of ethyl 4 (5)- methylimidazole-5 (4)-carboxylate (8) or 4-(5)-methylimidazole-5 (4)-carboxamide (13) via ...