Genotoxicity in oxazolidine derivatives: influence of the nitro group

…, MP De Meo, J Maldonado, R Nouguier…

Index: Vanelle, P; Meo, MP De; Maldonado, J; Nouguier, R; Crozet, MP; et al. European Journal of Medicinal Chemistry, 1990 , vol. 25, # 3 p. 241 - 250

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Citation Number: 33

Abstract

Abstract Tris-(hydroxymethyl)-aminomethane reacts with various aromatic or heterocyclic aldehydes, leading to new mono-or bicyclic oxazolidine derivatives. The importance of molecular surroundings of the nitro group has been evaluated by the genotoxic study of synthetised compounds using metronidazole and dimetridazole as reference compounds.