Anti-trypanosomal compounds. I. In vivo and in vitro activity of inhibitors of glycolysis in trypanosomes

D Betbeder, A Klaebe, JJ Perie, T Baltz

Index: Betbeder, D.; Klaebe, A.; Perie, J. J.; Baltz, T. European Journal of Medicinal Chemistry, 1990 , vol. 25, # 7 p. 549 - 555

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Citation Number: 8

Abstract

Abstract Carboxylated and phosphorylated esters of glycerol, possible inhibitors of the atypical glycolysis in trypanosomes have been synthesised and tested on Trypanosoma equiperdum in vitro and Trypanosoma brucei, on mice, and some of them also on glycerol phosphate dehydrogenase (GDH). Two of these compounds which showed no in vitro activity behaved as good competitive inhibitors of GDH; 3 other compounds were shown ...