Synthesis, characterization, and DNA-binding properties of (1, 2-diaminoethane) platinum (II) complexes linked to the DNA intercalator acridine orange by …

BE Bowler, KJ Ahmed, WI Sundquist…

Index: Bowler; Ahmed; Sundquist; Hollis; Whang; Lippard Journal of the American Chemical Society, 1989 , vol. 111, # 4 p. 1299 - 1306

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Citation Number: 104

Abstract

Abstract: We report the syntheses of intercalator-linked platinum complexes,[Pt {AO (CH2), en} C12] C1, where (CH,), is a polymethylene chain having n= 6 (9) or n= 3 (20) linking the DNA intercalator acridine orange (AO) to the Pt-binding ligand ethylenediamine (en). Single- crystal X-ray diffraction studies of the oxalate (ox) derivative of 9,[PtIAO-(CH2), en1 (ox)](NO3). 7H20 (lo), and of the ligand precursors,[AO (CH2) 60H] I (5) and [AO (CH,), OH ...