Coumarins as novel 17β-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer
K Harada, H Kubo, Y Tomigahara, K Nishioka…
Index: Harada, Koichiro; Kubo, Hideki; Tomigahara, Yoshitaka; Nishioka, Kazuhiko; Takahashi, Junya; Momose, Mio; Inoue, Shinichi; Kojima, Atsuyuki Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 272 - 275
Full Text: HTML
Citation Number: 30
Abstract
The synthesis and SAR studies of 3-and 4-substituted 7-hydroxycoumarins as novel 17β- HSD3 inhibitors are discussed. The most potent compounds from this series exhibited low nanomolar inhibitory activity with acceptable selectivity versus other 17β-HSD isoenzymes and nuclear receptors.
Related Articles:
[Alper, Howard; Zhou, Jian-Qiang Journal of Organic Chemistry, 1992 , vol. 57, # 13 p. 3729 - 3731]
[Emerson, David W.; Titus, Richard L.; Gonzalez, Rowena M. Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3572 - 3576]
Homologation of carbonyl compounds to aldehydes with lithium bis (ethylenedioxyboryl) methide
[Matteson, Donald S.; Moody, Robert J. Journal of Organic Chemistry, 1980 , vol. 45, # 6 p. 1091 - 1095]
[Emerson, David W.; Titus, Richard L.; Gonzalez, Rowena M. Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3572 - 3576]
[Stoss; Kaes; Eibel; Thewalt Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 2 p. 231 - 236]