Design and Synthesis of Isonucleosides Constructed on a 2-Oxa-6-thiabicyclo [3.2. 0] heptane Scaffold (1)

Y Yoshimura, K Asami, T Imamichi…

Index: Yoshimura, Yuichi; Asami, Kazuhiro; Matsui, Hiromitsu; Tanaka, Hiromichi; Takahata, Hiroki Organic Letters, 2006 , vol. 8, # 26 p. 6015 - 6018

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Citation Number: 11

Abstract

A novel method for the design and synthesis of an isonucleoside containing a 2-oxa-6- thiobicyclo [3.2. 0] heptane skeleton is described. 2, 2-Dimethyl-1, 3-dioxan-5-one 13 was converted into a dioxabicyclohexane derivative in six steps. After cleavage of the epoxide