Synlett

General and Easy Access to 11-Substituted 4-Hydroxy-2, 3, 4, 5-tetrahydro [1, 4] diazepino [1, 2-a] indol-1-one Derivatives

A Putey, G Fournet, B Joseph

Index: Putey, Aurelien; Fournet, Guy; Joseph, Benoit Synlett, 2006 , # 17 p. 2755 - 2758

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Citation Number: 3

Abstract

Abstract An efficient route to prepare the 4-hydroxy-2, 3, 4, 5-tetrahydro [1, 4] diazepino [1, 2- a] indol-1-one scaffold is described. The key reactions of the synthesis are an iodolactonisation followed by a lactone-to-lactam rearrangement. Various 11-substituted derivatives were obtained by palladium-mediated cross-coupling reactions.