Selective reduction of pyridazin-3-ones and ring contraction to pyrrolidin-2-ones and 3-pyrrolin-2-ones
GR Brown, AJ Foubister, B Wright
Index: Brown, George R.; Foubister, Alan J.; Wright, Brian Journal of the Chemical Society, Chemical Communications, 1984 , # 20 p. 1373 - 1374
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Abstract
Selective Reduction of Pyridazin-3-ones and Ring Contraction to Pyrrolidin-2-ones and 3-Pyrrolin-2-ones ... George R. Brown," Alan J. Foubister, and Brian Wright ICI Pharmaceuticals Division, Alderle y Park, Macclesfield, Cheshire, SK I0 4TG, UK ... Reduction of pyridazin-3-ones (la-d) with zinc dust in acetic acid affords selectively 4,5-di hydropyridazin-3-ones (2a-d), but N(2)-substituted (1) react further with excess of zinc to give equal amounts of pyrrolidin-2- ...
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