Acetylcholinesterase inhibitors: SAR and kinetic studies on ω-[N-methyl-N-(3-alkylcarbamoyloxyphenyl) methyl] aminoalkoxyaryl derivatives

…, A Bisi, M Bartolini, V Andrisano, V Cavrini…

Index: Valentini, Piero; Rampa, Angela; Bisi, Alessandra; Fabbri, Giuseppina; Andrisano, Vincenza; Cavrini, Vanni Medicinal Chemistry Research, 1995 , vol. 5, # 4 p. 255 - 264

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Citation Number: 63

Abstract

In this work, we further investigated a class of carbamic cholinesterase inhibitors introduced in a previous paper (Rampa et al. J. Med. Chem. 1998, 41, 3976). Some new ω-[N-methyl-N- (3-alkylcarbamoyloxyphenyl) methyl] aminoalkoxyaryl analogues were designed, synthesized, and evaluated for their inhibitory activity against both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The structure of the lead compound ( ...