Protease Probes Built from DNA: Multispectral Fluorescent DNA–Peptide Conjugates as Caspase Chemosensors

N Dai, J Guo, YN Teo, ET Kool

Index: Dai, Nan; Guo, Jia; Teo, Yin Nah; Kool, Eric T. Angewandte Chemie - International Edition, 2011 , vol. 50, # 22 p. 5105 - 5109

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Citation Number: 17

Abstract

The direct monitoring of enzyme activities is broadly useful in many fields, ranging from biochemistry to medicinal chemistry and biology.[1] A biological process often involves multiple enzymes, which can work independently or cooperatively to control a specific biological event. Monitoring their activities can provide markers of the progress of such a process (such as the cascade of caspase activity that occurs in apoptosis), and yield ...