Regioselective hydrolysis of diesters of (Z)-and (E)-2-methyl-butenedioic acids by PLE
…, V Partali, T Anthonsen, HW Anthonsen, L Kvittingen
Index: Schmid, Rudolf; Partali, Vassilia; Anthonsen, Thorleif; Anthonsen, Henrik W; Kvittingen, Lise Tetrahedron Letters, 2001 , vol. 42, # 48 p. 8543 - 8545
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Citation Number: 2
Abstract
Dimethyl, diethyl and dipropyl esters of (Z)-and (E)-2-methyl-butenedioic acids (citraconic and mesaconic acid) were hydrolysed by pig live esterase, PLE. For the diethyl esters the enzyme showed low regioselectivity for both the (Z)-and the (E)-isomers. However, the hydrolysis of dimethyl and dipropyl (Z)-2-methyl-butenedioic acid gave a ratio of the monoesters of 95: 5 and 85: 15.
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