Antineoplastic agents. 166. Isolation, structure, and synthesis of combretastatin C-1
SB Singh, GR Pettit
Index: Singh, Sheo Bux; Pettit, George R. Journal of Organic Chemistry, 1989 , vol. 54, # 17 p. 4105 - 4114
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Citation Number: 47
Abstract
A new cell growth inhibitory (PS EDw 2.2 pg/mL) phenanthraquinone designated combretastatin C-1 (2) has been isolated from the African tree Combretum caffrum. The structure (2) assigned combretastatin C-1 was based on high-resolution mass and NMR spectral analyses and confirmed by total syntheses. Synthetic routes 5b-6b-2 and especially 5c-6c-2 proved to be quite practical.
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