Synthesis and in vitro selective anti-Helicobacter pylori activity of pyrazoline derivatives

…, D Secci, P Chimenti, A Granese, D Rivanera…

Index: Chimenti; Bizzarri; Manna; Bolasco; Secci; Granese; Rivanera; Lilli; Scaltrito; Brenciaglia Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 603 - 607

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Citation Number: 68

Abstract

In order to develop new anti-Helicobacter pylori agents, a series of N1-substituted 3, 5- diphenyl pyrazolines P1–P13 was prepared and evaluated for their antibacterial activity. All synthesized compounds showed little or no activity against different species of Gram- positive and Gram-negative bacteria of clinical relevance and against various strains of pathogenic fungi. The same derivatives exhibited a significant degree of activity against a ...