Tetrahedron

The synthesis of imidazoline analogs of the kainoid family

H Baumgartner, AC O'Sullivan

Index: Baumgartner, Hansruedi; O'Sullivan, Anthony C. Tetrahedron, 1997 , vol. 53, # 8 p. 2775 - 2784

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Citation Number: 14

Abstract

In an effort to mimic the anthelmintic and insecticidal activties of kainic 1 and domoic 2 acids with compounds of simpler structure and much easier accessibility, the highly functionalised imidazolines 4, 27 and 28 were prepared. This involved a synthesis of suitably protected β- aminoglutamic acid derivatives as key intermediates, which were condensed with orthoesters and deprotected to yield the desired compounds.