Estrogen receptor binding and estrogenic/antiestrogenic effects of two new metabolites of nitromiphene, 2-[p-[2-nitro-1-(4-methoxyphenyl)-2-phenylvinyl] phenoxy]-N- …

PC Ruenitz, JR Bagley, CM Mokler

Index: Ruenitz, Peter C.; Bagley, Jerome R.; Mokler, Corwin M. Journal of Medicinal Chemistry, 1983 , vol. 26, # 12 p. 1701 - 1705

Full Text: HTML

Citation Number: 9

Abstract

Results Chemistry. Ketone 2 was prepared from 119 by reduction with sodium borohydride- stannous chloride in ethano120 (Scheme I). In contrast to the conventional procedure, we found it necessary to combine the sodium borohydride with 1, prior to adding the stannous chloride. Conjugate reduction was not observed under these conditions, although such reduction of some a,@-unsaturated nitroolefins with sodium borohydride has been ...