Journal of medicinal chemistry

Prostaglandin-H synthase inhibition by malonamides. Ring-opened analogs of phenylbutazone

JL Vennerstrom, TJ Holmes Jr

Index: Vennerstrom, Jonathan L.; Holmes, Thomas J. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 434 - 437

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Citation Number: 12

Abstract

Recent reports of serious concern regarding the safe clinical use of phenylbutazone and its hydroxylated metabolite (oxyphenbutazone) as antiinflammatory agents have prompted the further investigation of ring-opened (malonamide) derivatives as potentially preferable therapeutic derivatives. Earlier reports have claimed reduced toxicity among similar derivatives. These studies reveal the relative degree of prostaglandin-H (PGH) synthase ...