Synthesis of 2-substituted β-cyclodextrin derivatives with a hydrolytic activity against the organophosphorylester paraoxon

…, B Lefèvre, JC Debouzy, B Brasme, P Masson…

Index: Masurier, Nicolas; Estour, Franeois; Froment, Marie-Therese; Lefevre, Bertrand; Debouzy, Jean-Claude; Brasme, Bernard; Masson, Patrick; Lafont, Olivier European Journal of Medicinal Chemistry, 2005 , vol. 40, # 7 p. 615 - 623

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Citation Number: 41

Abstract

β-Cyclodextrin was substituted by an iodosobenzoic acid derivative to create a catalytic hydrolytic activity against neurotoxic organophosphorus agents. The catalytic moiety was introduced on a secondary hydroxy group at the position 2 of a glucose unit. Several β- cyclodextrin derivatives were obtained. In these derivatives, the methylene linker occupied all potential positions on the aromatic ring. Kinetic assays were carried out with paraoxon ...