Synthesis of 2-hydroxy-8'-(hydroxymethyl)-1, 1'-binaphthalene (iso-homo-binol). A new structural pattern in the binaphthyl realm

…, SC Lockhart, WL Mitchell, P Kočovský

Index: Vyskocil, Stepan; Lockhart, Stephen C.; Mitchell, William L.; Kocovsky, Pavel Collection of Czechoslovak Chemical Communications, 2003 , vol. 68, # 5 p. 907 - 916

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Abstract

Abstract The title compound 7 has been synthesized in a racemic form, using Suzuki coupling (8+ 15→ 16) as the key step. Pure enantiomer (S)-(-)-7 has been obtained by carbonylation of the known bromide (S)-(+)-12 followed by reduction of the resulting methyl ester (S)-(+)-18 with LiAlH 4.