(E)-. beta.-(Fluoromethylene)-m-tyrosine: a substrate for aromatic L-amino acid decarboxylase liberating an enzyme-activated irreversible inhibitor of monoamine …

…, JM Lacoste, P Bey, J Wagner, M Zreika…

Index: McDonald, Ian A.; Lacoste, Jean Michel; Bey, Philippe; Wagner, Joseph; Zreika, Monique; Palfreyman, Michael G. Journal of the American Chemical Society, 1984 , vol. 106, # 11 p. 3354 - 3356

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Citation Number: 53

Abstract

I- 2-a) R* mr, o OH a1 R* mr, o OH zyme-activated irreversible inhibitors of MAO. As the structures of 1 are closely related to phenethylamines, we envisaged the possibility of generating 1 from the corresponding a-amino acids 2 through the action of aromatic L-amino acid decarboxylase (AADC; EC 4.1. 1.28), an enzyme predominantly located in monoamine nerves.