Improved modular synthesis of thieno [3, 2-b] pyrroles and thieno [2, 3-b] pyrroles

S Malancona, JIM Hernando, B Attenni, JM Ontoria…

Index: Malancona, Savina; Hernando, Jose I. Martin; Attenni, Barbara; Ontoria, Jesus M.; Narjes, Frank Tetrahedron Letters, 2009 , vol. 50, # 14 p. 1625 - 1628

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Abstract

A convenient modular synthesis for the construction of densely functionalized thieno [3, 2-b] pyrroles, allosteric inhibitors of the Hepatitis C virus NS5B polymerase, is described. The route allows the introduction of substituents in positions 4, 5, and 6 of the thienopyrrole scaffold and can also be applied to the regioisomeric thieno [2, 3-b] pyrrole core.