Synthesis of Aryl (di) azinyl Ketones through Copper??and Iron??catalyzed Oxidation of the Methylene Group of Aryl (di) azinylmethanes

J De Houwer, K Abbaspour Tehrani…

Index: De Houwer, Johan; Abbaspour Tehrani, Kourosch; Maes, Bert U. W. Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2745 - 2748

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Citation Number: 39

Abstract

Aryl (di) azinyl ketones are very useful intermediates in the synthesis of pharmaceuticals, such as antihistamines, antimalarials, antiarrhythmic agents, β2-adrenergic agonists, and anticancer therapeutics.[1] The oxidation of aryl (di) azinylmethanes is an attractive approach to synthesize these compounds. Classical conditions for this transformation often apply (more than) stoichiometric quantities of hazardous oxidants, such as potassium ...