Synthetic Communications

On the Alkylation of 5-Fluorouracil-Some Recent Findings

U Sanyal, SK Chakraborti

Index: Sanyal, Utpal; Chakraborti, S. K. Synthetic Communications, 1982 , vol. 12, # 13 p. 1047 - 1054

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Citation Number: 3

Abstract

Abstract Since its discovery 5-fluorouracil 1 (1, 5-FU), an important anticancer drug, has been the subject of study for the preparation of some suitable derivatives2 which may have better therapeutic efficacy. These are prepared through silylation method3, mercuri salt method4 and direct alkylation method5 of 5-FU. It was reported5 that the direct alkylation of 5-FU with saturated and allylic type halides under controlled conditions occur at N3 (3-) ...