The synthesis and evaluation of some coumarin derivatives as fluorescent indicators of nitroreductase activity

AL James, JD Perry, SP Stanforth

Index: James, Arthur L.; Perry, John D.; Stanforth, Stephen P. Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 2 p. 515 - 517

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Citation Number: 11

Abstract

Many bacteria have the ability to reduce aromatic nitro compounds and the detection of nitroreductase activity may offer a useful means of analysing biological and environmental samples for the presence of microorganisms. The reduction of a series of seven non- fluorogenic nitrocoumarins 1 to their corresponding fluorogenic hydroxylamine derivatives 2 or amine derivatives 3 has been recently investigated for 30 strains encompassing 24 ...