Friedel-Crafts acylation of methyl ester of phenylacetic acid: a reinvestigation

…, C Giordano, A Brambilla, R Annunziata

Index: Uggeri, Fulvio; Giordano, Claudio; Brambilla, Adriano; Annunziata, Rita Journal of Organic Chemistry, 1986 , vol. 51, # 1 p. 97 - 99

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Citation Number: 6

Abstract

In 1966 Morgan3 reported conclusive results on the Friedelqrafts acylation of alkyl esters of phenylacetic acid with several acyl halides: a mixture of alkyl esters of acylphenylacetic acid (isomers ratio ortho/meta/para=(4-6)/(38-49)/(44-58)) was obtained, thus showing the lack of positional selectivity of the reaction. R e~ ently,~*~ it has been reported that the methyl ester of phenylacetic acid is acylated with 2-bromopropionyl chloride, in the presence of ...