Synlett

A focused library of tetrahydropyrimidinone amides via a tandem Biginelli-Ugi multi-component process

S Werner, DM Turner, MA Lyon, DM Huryn, P Wipf

Index: Werner, Stefan; Turner, David M.; Lyon, Michael A.; Huryn, Donna M.; Wipf, Peter Synlett, 2006 , # 14 p. 2334 - 2338

Full Text: HTML

Citation Number: 17

Abstract

Abstract A second generation focused library of 30 tetrahydropyrimidinone amides was prepared. The design was based on the structure of an Hsp70 modulator. This small library demonstrates the utility of tandem multi-component reactions in structure-activity relationship studies of biological lead molecules. The tandem Biginelli-Ugi multi-component reaction facilitated the effective variation of four different substituents and allowed the synthesis of ...