In vitro evaluation of phosphocholine and quaternary ammonium containing lipids as novel anti-HIV agents

…, CJ Marasco Jr, SL Morris-Natschke…

Index: Meyer, Karen L.; Marasco, Canio J.; Morris-Natschke, Susan L.; Ishaq, Khalid S.; Piantadosi, Claude; Kucera, Louis S. Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1377 - 1383

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Citation Number: 56

Abstract

A series of synthetic lipids containing a two-or three-carbon backbone substituted with a thio, oxy, or amidoalkyl functionality and either a phosphocholine or quaternary ammonium moiety was evaluated as potential anti-HIV-1 agents. Several analogues were identified as possessing activity with the most promising compound being rac-3-octadecanamido-2- etholrypropylphosphocholine (8). Compound 8 exhibited an ICso for the inhibiton of ...