Synthesis of Cannabinoid Model Compounds. Part 3.(6aR, 10aR)??N??ethyl?螃?8??tetrahydrocannabinol??18??amide,(6aR, 10aR, 17 RS)??N??ethyl??17??methyl?螃?8?? …

B Schmidt, I Franke, FJ Witteler…

Index: Schmidt; Franke; Witteler; Binder Helvetica Chimica Acta, 1983 , vol. 66, # 8 p. 2564 - 2571

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Citation Number: 7

Abstract

Abstract The novel cannabinoids (6aR, 10aR)-N-ethyl-Δ 8-tetrahydrocannabinol-18-amide (15) and (6aR, 10aR, 17 RS)-N-ethyl-17-methyl-Δ 8-tetrahydrocannabinol-18-amide (16), designed as cannabinoid affinity ligands, were synthesized from the corresponding acids 11 and 12via the N-hydroxysuccinimide esters. Amide 16 was tested in the rat and was generalized to Δ 9-tetrahydrocannabinol, being 5 times less potent than the training drug. ...