Stereoselective Mannich reactions catalyzed by Tröger's base derivatives in aqueous media
…, X Chen, Y Wan, L Ye, H Xin, H Xu, C Yue, L Pang…
Index: Wu, Hui; Chen, Xiu-mei; Wan, Yu; Ye, Ling; Xin, Hai-qiang; Xu, Hua-hong; Yue, Cai-hui; Pang, Li-ling; Ma, Rui; Shi, Da-qing Tetrahedron Letters, 2009 , vol. 50, # 9 p. 1062 - 1065
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Citation Number: 57
Abstract
A Tröger's base derivative (5, 12-dimethyl-3, 10-diphenyl-1, 3, 4, 8, 10, 11-hexaazatetracyclo [6.6. 1.02, 6.09, 13] pentadeca-2 (6), 4, 9 (13), 11-tetraenes) was used as an efficient catalyst for the three-component Mannich reactions of aromatic aldehydes and aromatic amines with ketones in water at room temperature. This rapid reaction afforded the corresponding β- amino ketones in good yields with excellent stereoselectivity.
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