Angiotensin-converting enzyme inhibitors. New orally active antihypertensive (mercaptoalkanoyl)-and [(acylthio) alkanoyl] glycine derivatives

…, JW Skiles, BE Williams, RD Youssefyeh…

Index: Suh, John T.; Skiles, Jerry W.; Williams, Bruce E.; Youssefyeh, Raymond D.; Jones, Howard; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 57 - 66

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Citation Number: 29

Abstract

A variety of N-substituted (mercaptoalkanoy1)-and [(acylthio) alkanoyl] glycine derivatives was synthesized and their ability in inhibiting the activity of angiotensin-converting enzyme (ACE) was examined in vitro and in vivo. The acylthio derivatives prepared are assumed to act as prodrugs since they are much less active than the corresponding free SH compounds in vitro and can be expected to act in vivo only after conversion to the free sulfhydryl ...