Tetrahedron Letters

Reactions of the N, N-dialkylpyridylcarboxylic amides with lithium amides. Regioselective lithiation of N, N-diisopropylpyridylcarboxylic amides, a useful method for …

J Epsztajn, Z Berski, JZ Brzeziński, A Jóźwiak

Index: Epsztajn, Jan; Berski, Zbigniew; Brzezinski, Jacek Z.; Jozwiak, Andrzej Tetrahedron Letters, 1980 , vol. 21, p. 4739 - 4742

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Abstract

Abstract The behaviour of the N, N-dimethyl-, N, N-diethyl-and N, N- diisopropylpyridylcarboxylic amides in the reactions with Et 2 NLi and iPr 2 NLi, and a convenient way of synthesis of 2, 3-and 3, 4-disubstituted pyridines, by the direct lithiation of N, N-diisopropylamides leading subsequently to the ortho new C C bonds formation, are described.