Syntisis of 4-Demethoxy-7, 11-dideoxydaunomycinone

…, VH Deshpande, K Ravichandran, BR Rao

Index: Rao, A V Rama; Deshpande, V H; Ravichandran, K; Rao, B Ramamohan Synthetic Communications, 1983 , vol. 13, # 14 p. 1219 - 1224

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Abstract

Abstract Our continued interest in the total synthesis of natural and unnatural antitumor anthracyclines1 especially the aglycones such as daunomycinone (1) 2 and 4- demethoxydaunomycinone (2) 3, 11-deoxydaunomycinone (3) 4 and 4-demethoxy-11- deoxydaunomycinone (4) 5 led us to probe methods of obtaining these products of absolute enantitomeric purity. Earlier it was demonstrated that the AB ring synthon 5 having a chiral ...