Stereoselective synthesis of aryl γ, δ-unsaturated β-hydroxyesters by ketoreductases

Z Dai, K Guillemette, TK Green

Index: Dai, Zhipeng; Guillemette, Kate; Green, Thomas K. Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 97, p. 264 - 269

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Abstract

Abstract The biocatalytic reduction of aryl γ, δ-unsaturated-β-ketoesters was evaluated utilizing 24 different commercially available ketoreductases. In all cases, both (R) and (S)- enantiomers of γ, δ-unsaturated β-hydroxyesters were synthesized by one or more ketoreductases in excellent optical purity and yields.

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