Titanocene-catalyzed cyclocarbonylation of o-allyl aryl ketones to γ-butyrolactones

…, FA Hicks, SL Buchwald

Index: Kablaoui, Natasha M.; Hicks, Frederick A.; Buchwald, Stephen L. Journal of the American Chemical Society, 1997 , vol. 119, # 19 p. 4424 - 4431

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Citation Number: 80

Abstract

A method for the transformation of o-allyl aryl ketones to γ-butyrolactones using a catalytic amount of Cp2Ti (PMe3) 2 or Cp2Ti (CO) 2 is described. This catalytic “hetero Pauson- Khand”-type process proceeds via the carbonylation of an oxatitanacycle followed by thermally-induced reductive elimination to form a γ-butyrolactone and to regenerate the catalyst. We have investigated the scope and limitations of this catalytic methodology. Our ...